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doi: 10.2169/internalmedicine.46.0221 Summary Keywords alpha lipoic acid, chronic sleep deprivation, metabolic function, antioxidant, anti-inflammatory activity Citation Chang H-M, Lin H-C, Renn T-Y, Liu Y-C, Yen K-J, Liao C-K, Tikhonova MA, Amstislavskaya TG, Singh SK and Chen L-Y (2026) Manifold hepatoprotective actions of -lipoic acid on metabolic function through redox regulation, inflammatory modulation, and anti-apoptosis after chronic sleep-deprived injury

The following comparison summarizes the key considerations: For patients with intact GI absorption, oral high-dose supplementation (1,000 to 2,000 mcg daily) provides a convenient and cost-effective path to correcting deficiency

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