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These diverse factors of RAM interact mutually, resulting in the relentless progression of RA [7, 16]

Molecular docking simulations were performed to investigate the binding interaction of hesperidin and its aglycone derivative, hesperetin, with key cellular proteins essential for SARS-CoV-2 entry, namely transmembrane serine protease 2 (TMPRSS2), which plays a crucial role in the activation of viral glycoproteins, including the spike protein of coronaviruses and hACE2, a membrane-bound enzyme that serves as the cellular receptor for the spike protein of SARS-CoV-2

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