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NAD + deficiency, however, contributes to a spectrum of diseases including metabolic diseases, cancer, aging and neurodegeneration disorders

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Serum and liver vitamin B12 concentrations were found to be significantly elevated for 24 days in lambs treated with a single 2 mg subcutaneous vitamin B12 injection, compared to untreated controls ( There have also been a few case series published reporting the general efficacy of the subcutaneous route at normalising plasma B12 levels