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Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite

Antimicrob Agents Chemother 44(2):248254 Bocian-Ostrzycka KM, asica AM, Dunin-Horkawicz S, Grzeszczuk MJ, Drabik K, Dobosz AM, Godlewska R, Nowak E, Collet J-F, Jagusztyn-Krynicka EK (2015) Functional and evolutionary analyses of Helicobacter pylori HP0231 (DsbK) protein with strong oxidative and chaperone activity characterized by a highly diverged dimerization domain

7 In fact, xCT is considered to be the main transporter of cystine in cancer (Table 1) 25,26,27 and its expression is controlled by nuclear factor erythroid 2-related factor 2 (NRF2), a master regulator of the cellular redox state, 28 highlighting the importance of xCT in an oxidative stress-resistant cancer cell phenotype