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Network analysis of HQEZ revealed that the 4 core compounds (folate, curcumin, quercetin and kaempferol) could affect chemoresistance and 5-FU sensitivity related targets, such as AKT1, EGFR, P-gp, BCRP, MMP2, TLR4, TLR9 and so on [157]

Given the vicious circle between ROS production and mitochondrial dysfunction mentioned above, it has been reasonably hypothesized that, in some individuals with pre-existing sub-optimal mitochondrial function, an infection can tip the host into a chronic and self-perpetuating metabolically imbalanced non-resolving state characterized by mitochondrial dysfunction, where ROS continually drive inflammation (204)

Body composition changes usually take longer and depend on nutrition, exercise, sleep, lab results, dosing, and consistency

The table below summarizes the most commonly used GHK-Cu dosage protocols across these goals