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The Endocrine Society publishes clinical practice guidelines on obesity management that include sections on incretin-based therapies

Pernicious anemia is a chronic condition characterized by the inability to absorb vitamin B12, leading to deficiency and related complications. Other issues like problems after stomach surgery or diseases like Crohns also might need Vitamin B12 injections

[1] Unlike the folic acid derivative leucovorin, folic acid is not clinically useful in offsetting the action of folate reductase inhibitors because it requires the enzyme dihydrofolate reductase for activation

B12 deficiency may be caused by low intake, medication interactions or malabsorption