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Furthermore, SHH has been demonstrated to play a significant role in nerve injury: the morphogen has been found upregulated in Schwann cells after nerve injury and has stimulated expression of neurotrophic factors including the brainderived neurotrophic factor (BDNF) that supports survival and neurite outgrowth in motoneurons (Hashimoto et al., 2008)

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coli , it could be adapted for use in the complex proteomes of mammals