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*Correspondence: Zhang Wang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The human copper-binding peptide GHK-Cu (glycyl-l-histidyl-l-lysine) is a naturally occurring tri-peptide found in human plasma and released from tissues during injury

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Notably, metformin has been shown to ameliorate oxidative stress as an antioxidant in individuals with type 2 diabetes 16,17,18