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Antibiotic potentiation in multidrug-resistant Gram-negative pathogenic bacteria by a synthetic Peptidomimetic

Powell JJ, Faria N, Thomas-McKay E, Pele LC

Alterations in the normal function of excitatory amino acid carrier 1 affect cysteine transport and GSH synthesis impairing zinc homeostasis (the thiol group of GSH can function as a principal Zn 2+ chelator for the maintenance of Zn 2+ homeostasis in neurons) and oxidative stress, enhancing susceptibility to ischemia-induced neuronal cell death in the hippocampus (162164)