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Finally, direct oxidative modification (and inhibition) of the PTP that dephosphorylate the Src activation loop site also contribute to redox-activation of Src kinase activity ( There is limited evidence that free radicals can directly oxidize membrane phospholipids

The activation of resident hepatic stellate cells into myofibroblasts to produce matrix proteins is the crucial step in fibrogenesis (Mederacke et al., 2013)

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