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However, Clazosentan, administered at 15 mg/h for up to 14 days, did not demonstrate a significant effect on preventing clinical deterioration due to DCI (60, 61)

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enhancing protein folding via the inositol-requiring enzyme 1 (IRE1) and X-box binding protein 1 (XBP1) signaling cascade (Ning et al., 2011), and inducing apoptosis and ER-associated degradation by activating transcription factor 6 (ATF6) associated pathway (Lebeaupin et al., 2018)

To validate the specificity of this interaction, we also generated a murine NKG2D-Ig fusion protein and observed similar C