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In addition, research has demonstrated that specific inflammatory genes, including IL-1, IL-6, and TNF-, are prominently expressed in endothelial cells, fibroblasts, and macrophages in older populations with POP

The hypomethylated CpG sequence in mtDNA binds specifically to the N-terminal part of the C-shaped leucine-rich repeat region of TLR9, mediating TLR9 activation (170, 171)