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10.3892/mmr.2024.13378 159 HuangJ.YangJ.ShenY.JiangH.HanC.ZhangG.et al

It also protects against alcohol-induced liver injury by modulating the DEAD-box helicase 5/Signal Transducer and Activator of Transcription 1 (DDX5/STAT1) signaling axis (Wang X

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The latest evidence indicates that high concentrations of lactate are not merely metabolic waste but key signaling molecules that induce lactylation modifications on histones and non-histone proteins such as high mobility group box 1 (HMGB1) (11)