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IS is approximately 90% bound to albumin in blood circulation and is primarily secreted and excreted through organic anion transporters (OAT1 and OAT3) in renal proximal tubules (113)

More recently this view has been challenged by the discovery of several regulated non-apoptotic cell death pathways activated in specific disease states, including poly(ADP-ribose) polymerase-1 (PARP-1) and apoptosis inducing factor 1 (AIF1)-dependent parthanatos, caspase-1- dependent pyroptosis and receptor interacting protein kinase 1 (RIPK1)-dependent necroptosis (Bergsbaken et al., 2009

Acta Pharmacol Sin 43:529540

This is the most reliable visual indicator of significant degradation