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126 A double-blind, placebo-controlled trial of magnesium with malic acid showed no benefits during the 4-week blinded phase with a low dose of 150 mg magnesium and 600 mg malic acid, but showed significant benefits in the severity of pain and tenderness scores in an open-label extension of the study after 2 and 6 months, with a dose in excess of 400 mg magnesium and 1600 mg malic acid

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Many direct or indirect markers of oxidative stress, including malondialdehyde, thiobarbituric acid, and glutathione disulfide, have been found in urine, plasma, sputum, and BAL fluid of patients with asthma, and the level of the markers correlated with the severity of the disease [6769]