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doi: 10.1016/j.biopsych.2016.06.017 52 KaufmanMJJanesACHudsonJIBrennanBPKanayamaGKerriganARet al

GSH in peripheral immune cell infiltration Several studies indicate that neuroinflammatory changes associated with neurodegeneration compromise the BBB or its function by disrupting transport systems, facilitating the infiltration of immune cells, and influencing the BBBs role as a signaling interface

This review of the evidence indicating whether UA may have a protective role in the development and/or progression of PD draws on the findings of reduced serum UA in PD, critically assesses the more equivocal genetic results, and discusses experimental observations that UA may provide protection against the pathogenic mechanisms of PD

Consequently, as catalase functions, it provides a coherent oxidative pulse to the H-bonded network that effectively unzips H 2 O 2 molecules into water and oxygen as far as it extends from the enzyme