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Impaired cell signaling pathways also disrupt this cycle, and once this happens, pigment can no longer be regenerated, leading to permanent greying

Chronic stress is a physical state

PMID: 1371669

Other Nrf2-dependent genes, including GPX4, GSH and NADPH synthesis genes, as well as epigenetic regulators of lipid hydroperoxides, contribute to its ferroptosis-inhibitory effects (117119)