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Peer review Peer review information Nature Communications thanks Rudolf Oehler, Robert Hoffman and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

425,426 Aging, smoking, cardiovascular disease, obesity, high-fat diet, hypertension, excessive sun exposure, and other factors can induce mtDNA damage and increase ROS production, resulting in mitochondrial dysfunction and ultimately leading to RPE cell damage

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