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Description

Fourth, age at parental recognition of first symptoms among children with autism with developmental regression (19.8 months) was similar to that of children with autism without developmental regression (19.3 months)

This dual nature has contributed to theoretical concerns

Elevated HMGB1 levels have been detected in the blood of patients, where it interacts with receptors such as RAGE and TLR4, forming complexes with IL-1 or LPS to activate proinflammatory signaling pathways (Shimizu et al., 2017)