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Blocking both xCT and GGCT synergistically depleted intracellular cysteine and GSH, leading to excessive accumulation of reactive oxygen species (ROS), lipid peroxidation, and ferroptotic cell death in glioblastoma cells

Phase 3 Detoxification: Elimination Through Stool, Urine, and Sweat While Phase 1 and Phase 2 detoxification occur primarily in the liver and are responsible for transforming and neutralizing toxins, Phase 3 detoxification is the non-negotiable final step the physical removal of those compounds from the body

The peptides were fragmented using higher-energy collisional dissociation (normalized collision energy of 28), and the fragment ions were detected using an Orbitrap

TCL/RHOJ plasma membrane localization and nucleotide exchange is coordinately regulated by amino acids within the N terminus and a distal loop region