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Obesity(4, 5) and diabetes mellitus(6, 7) are plasma cell disorder risk factors, and obesity increases the progression risk of MGUS.(810) Inflammatory and western diets are associated with metabolic disorders and linked to both MGUS(11) and MM in epidemiologic studies.(1214) High-fiber, plant-based diets (HFPBD) may reduce the risk of metabolic-disorder-associated disease progression through mechanisms reducing inflammation.(15) We hypothesized that an HFPBD intervention (NUTRIVENTION trial) would be feasible and promote weight loss, potentially favorably altering MM disease trajectory through metabolic-, microbiome-, and immune-based changes

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Patients are given an intravenous solution of the vitamin of their choice