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Here, we highlighted the studies that analyze strategies to delay or prevent the progression of these diseases using TRP modulation, with some encouraging results, as well as highlighting unanswered questions yet to be studied

For peripheral nerve analysis, a 5-mm-long piece of tail 15 mm distal from the tail base was collected from each sacrificed animal, fixed in 4% formaldehyde in phosphate buffer (pH 7.4), decalcinated, and impregnated with 1% osmium tetroxide for a few days

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Weight gain, particularly around the abdomen, is another common concern