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However, despite these advancements, challenges remain in large-scale production, regulatory approvals, and long-term safety issues that need to be addressed for the future use of CsNP-based therapies in neurological disorders

Moreover, BRNPs have better efficacy in ROS-overproducing tumor cells than in ROS-low-expressing tumors

Even a recent 2026 review concludes the same thing that GHK-Cu appears safe but the evidence is largely preclinical and comprehensive human RCTs are lacking (Wojcieszuk et al., 2026)