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ground truth similarity assessment Peak signal-to-noise ratio (PSNR), structural similarity index (SSIM) (Wang et al., Human aging Pilot study part 1: Voxel-based analysis on the hippocampal circuit Voxel-based analysis ( Figures 4B,C ) was performed by first transforming the non-contrast images using a diffeomorphic registration algorithm (Avants et al., t -test