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85 , 95 , 96 , 121 Children with autism show significantly elevated oxidative stress, as indicated by the increased GSSG/GSH ratio (glutathione is the primary antioxidant in the body) and increased plasma nitrotyrosine

Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 12 trial

The environment of serum allows the non-reduced form of TrxR1 to dominate

For example, mitochondrial ferritin reduces iron content by storing iron, GPX4 and dihydroorotate dehydrogenase (DHODH) in the mitochondria eliminate lipid peroxides (Mao et al., 2021), and CDGSH iron sulfur domain 1 (CISD1) and voltage-dependent anion channel (VDAC) regulate iron concentration and respiratory substrate content in mitochondria, respectively (Lemasters, 2017