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Evidence indicates the risk for infection is highest when using Biologics compared to traditional DMARDs, but there is some risk associated with use of non-biologics such as methotrexate as well (Komano et al, 2011

However, in another study, the addition of pelareorep to the carboplatin/paclitaxel regimen was both safe and showed promising clinical activity in patients with advanced malignant melanoma, with a mPFS of 5.2 months, mOS of 10.9 months and 1-year OS rate of 43% (NCT00984464) [124], warranting further randomised phase III trials

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