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Stem cells have the unique ability to differentiate into various cell types, making them invaluable in regenerative medicine

Together, hiPSC and directed reprogramming technology hold promise for advancing our understanding of mitochondrial disorders like LS, while allowing for targeted high-throughput drug screening in human cell lines and advancing precision medicine (Villalon-Garcia et al., 2020)

This may suggest the potential for enhanced muscle growth and regenerative capabilities

Other therapies that have been utilized include corticosteroids, acetazolamide, mannitol, glycerin, topiramate, and therapeutic lumbar puncture.71,73,77 There is a report of the use of mannitol and acetazolamide together with the suspension of ATRA to decrease the CSF pressure thereby improving the headaches, diplopia, nausea and vomiting in two days and improvement of papilledema in seven days.78 Topiramate, an anticonvulsant and carbonic anhydrase inhibitor, may also be used in cases not responsive to acetazolamide to improve symptoms.74 The temporary suspension of ATRA/ATO is recommended when there is diagnostic suspicion of PTC in patients with APL