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Available: www.hc-sc.gc.ca/dhp-mps/prodpharma/applic-demande/guide-ld/label_stand_guide_ld-eng.php (accessed 2012 Jan

All treatments should be subjected to the rigor of well-designed, double-blind, placebo-controlled clinical trials

Tolvaptan, which is a V2-receptor antagonist, has been demonstrated in experimental studies and a large randomized controlled trial involving 1,445 patients with autosomal dominant PKD to limit the progression of the disease