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For instance, single-cell RNA sequencing of microglia in germ-free vs colonized mice with neurodegenerative pathology can pinpoint microglial genes influenced by the microbiome

Cross talk between alcohol-induced oxidative stress and HCV replication

The suggestion is that reduced GR activity and therefore less 'reduced glutathione' may be implicated in Irritable Bowel Syndrome - possibly because it has less defenses against free radicals, the cause of oxidative stress