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This calpain-mediated rearrangement of the erythrocyte cytoskeleton results in membrane blebbing [88, 89]

In a recent randomized, placebo-controlled trial conducted to investigate the effect of NAC and working memory-training to reduce cocaine use and craving and to improve inhibition, a 25-day treatment with NAC (2.4 g/day) was associated with fewer cocaine problems and cocaine-positive urines compared with placebo [129]