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Nutr Metab 17:14 Zhao Y-Y, Wu S-P, Liu S, Zhang Y, Lin R-C (2014) Ultra-performance liquid chromatographymass spectrometry as a sensitive and powerful technology in lipidomic applications

T., Coyle, J

10.1371/journal.pone.0144234 45 LondonoJ.SaldarriagaE

However, it is important to note that clinical translation of these approaches does face several challenges: profound metabolic and molecular heterogeneity between patients (and even within tumors), difficulties in achieving adequate drug penetration across the blood-brain barrier, and the risk of toxicity in normal cerebral tissue