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For instance, certain antibiotics can actually stop your body from efficiently breaking down caffeine, which may enhance the potency of caffeine's effects

A notable increase in ORMDL3 expression, increased expression of epithelial-mesenchymal transition (EMT)-related markers, including E-cadherin, vimentin, and fibroblast-specific protein 1 (FSP-1), and a positive correlation with the severity of airway remodeling was observed in the OVA-induced mice model (122)

This may explain why some people feel worse when taking high-dose B vitamins