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A critical translational note: these effects appeared in obese models only

We elucidated the underlying mechanism by which OroA decreases oxidative stress and reverses SHP-2 oxidative inactivation, thereby suppressing the Src/Syk/PLC2/(Ca 2+ + PKC) signaling pathway downstream of GPVI activation by collagen

Mice lacking radixin, which links actin filaments to plasma-membrane proteins, develop conjugated hyperbilirubinemia associated to retrieval of Mrp2,122 and the same hols true for obstructive and estrogen-induced cholestasis, where a disturbed colocalization of Mrp2 and radixin is associated with Mrp2 endocytic internalization.123 Interestingly, the internalization of Mrp2 that occurs after hepatic ischemia-reperfusion is coincident with a virtual loss of radixin expression.124 Mrp2 retention in the apical membrane also requires interaction with the PDZ-domain protein, PDZK1.125 Since other canalicular transporters, such as Bsep, Mdr1 and Mdr2, do not contain obvious PDZ-interacting motifs, regulation by actin of the localization of these transporters must occur through a different subset of proteins

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