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1 Introduction Paclitaxel is a highly effective chemotherapeutic agent widely used in the treatment of various cancers, including breast, ovarian, lung, head, and neck cancers (Abu Samaan et al., 2019)

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first proposed the concept of oxidative stress, either caused by an increase in free radical production or a reduction in the scavenging capacity of the body, leading to disorders in the oxidation and antioxidant systems, resulting in oxidative damage by free radical accumulation (Sohal and Allen, 1990)