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Hydrogen peroxide, a ROS of major biological significance, can form as a result of the reaction of superoxide and also can be generated by specific enzymes ( synthesis and its subsequent dismutation to H 2 O 2 in the apoplast, is a common response to pathogens, elicitors, wounding, heat, ultra-violet light, and ozone ( 2 O 2 has a key signaling role in plants ( 2 O 2 can induce gene expression and modulates signaling proteins, such as protein phosphatases (PP), protein kinases (PK), transcription factors and calcium channels that are located in the plasma membrane or elsewhere ( ROS AND NO SIGNALING IN THE HYPERSENSITIVE RESPONSE A well-documented form of plant programed cell death (PCD) is the HR, characterized by the rapid cell death surrounding infection sites

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Routine clinical follow-up should be considered if patients experience persistent burning that doesn't resolve quickly after injection, burning that progressively worsens with successive doses, or development of nodules, lumps, or skin changes at injection sites