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confirmed that genistein can inhibit cell proliferation, and induced apoptosis of nasopharyngeal CSCs via suppressing the tumorsphere formation capacity, decreasing the number of EpCAM + cells, and downregulating the expression of nasopharyngeal CSCs markers, as well as suppressing Sonic Hedgehog (SHH) signaling mainly by downregulating the levels of SHH, SMO, and GLI 1

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