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In severe cases, bacterial translocation and systemic inflammatory spread can lead to mortality rates as high as 50% 72

For this reason, obtaining adequate vitamin B12 can be more challenging for people who consume little or no animal products, but there are several other factors that can also increase the risk of deficiency

A phase I safety study in healthy adults confirmed that subcutaneous MOTS-c injections at doses up to 10 mg produced no serious adverse events, with a pharmacokinetic profile supporting once-daily or every-other-day dosing [3]

In some cases, additional systematic symptoms may appear, including anorexia, sluggishness, vomiting, diarrhea, pneumonia, and discharge from the eyes (conjunctivitis)