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Given its benefits, Allen and Zenker say the best groups to supplement l-carnitine are those who: Are older adults Have chronic conditions such as prediabetes, heart disease, or Alzheimers Are on a weight loss journey Have PCOS Want to improve their athletic performance Follow a vegan or vegetarian diet On the flip side, the following groups might want to avoid L-carnitine supps, including those who: Take anticoagulants, or drugs to prevent blood clots, like warfarin or aspirin, Walker says