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tabacum cell suspension to elevated temperature (55C) also resulted in increased GR activity (Locatto et al., 2009)

Environmental factors such as cold weather, low humidity, harsh soaps, and frequent washing can exacerbate dryness

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Emerging human studies provide encouraging translational support, showing that luteolin, administered primarily as ultramicronized PEA-luteolin, reduces key inflammatory cytokines (IL-6, IL-1, TNF-), mast-cell mediators, and oxidative stress biomarkers ( Therefore, this review aims to synthesize current mechanistic, preclinical, and translational evidence on luteolin across major female reproductive disorders and to evaluate its potential as a multi-target therapeutic candidate