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Several studies supported an association between Retts syndrome and disturbances of cerebral methyl-group pools, including folate, SAMe, and the SAM/SAH ratio, and speculated on a compromised DNA-methylation [93,94,95,96]

At its base is 63% Hippophae rhamnoides (more commonly known as sea buckthorn) water, rich in naturally occurring antioxidants, paired with 5% niacinamide and 2% tranexamic acid to target dullness and dark spots without feeling stingy like a peel

There is also a critical need for well-designed long-term safety studies addressing the potential side effects of chronic polyphenol supplementation, as current data are mainly limited to short-term animal experiments or isolated compounds, and results from these do not always translate directly to humans (121)