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Under normal conditions, spliceosomal components are mainly localized in the nucleus

Compared to healthy young adults, who have a high proportion of Firmicutes , older adults demonstrate a decrease in Bifidobacteria and an increase in Bacteroidetes , as well as a decline in gut microbial diversity, with a reduction in the relative abundance of core species and an augment in the colonization of opportunistic species ( Betaproteobacteria ) (Biagi et al., 2017)