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Structural Modifications Cagrilintide incorporates specific molecular modifications that distinguish it from endogenous amylin

10.1021/pr.500431j 44 KimelbergH

These and other heavy metals are recognized systemic toxicants that are associated with a number of human health disorders, including chronic diseases such as cardiovascular diseases, neurological disorders, renal, lung, and dermal diseases, and various types of cancer

Thus, a hybrid strategy using gut-on-chip platforms for mechanistic hypothesis testing followed by targeted validation in animal models offers a robust pathway to translate findings to human-relevant insights