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Vitamin C helps "spare" glutathione by taking on some of the antioxidant workload, and glutathione, in turn, helps recycle Vitamin C after it has neutralized a free radical

Up-regulated GCL expression to ensure GSH elevation under conditions of inflammatory and oxidative stimulation seems reasonable, as GCL activity is considered especially important for maintaining GSH levels to provide relevant antioxidant defense

Thus, substantial and mounting evidence supports a direct contributory role of gut microbiota as a participant in CVD pathogenesis, and preclinical studies indicate that the therapeutic targeting of microbial contributors to the TMAO metaorganismal pathway may hold promise as a novel approach for the prevention or treatment of CVD