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Hyperactivated M1 alveolar macrophages are taken over by SARS-CoV-2 allowing for viral infection and spread, while M2 alveolar macrophages can degrade the virus and limit its spread (Knoll et al., 2021

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By activating FOXO/MsSOD pathway, SIRT1 increases the expression of manganese superoxide dismutase (MnSOD) and catalase, counteracting oxidative stress and promoting damage repair (Zhang et al., 2017