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Nuclear factor-kappa B (NF-B) and activator protein-1 (AP-1) are key transcriptional regulators of the inflammatory response, promoting the upregulation of pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor- (TNF-)

Furthermore, sex steroids crosstalk with several growth factors such as the epidermal growth factor (EGF) (Smith et al., 2002), vascular endothelial growth factor (VEGF) (Schmahl et al., 2008), nerve growth factor (NGF) (Schmahl et al., 2008

Since the whole review is based on animal studies, we could not derive clear conclusions or recommendations for surgical treatment augmentation in the human population, but focused to give an insight into every possible dietary, nutritional or supplement-related influence