Mechanism of Action and Target Biology NNMT Enzyme and Function: Nicotinamide N-methyltransferase (NNMT) catalyzes the SAM-dependent methylation of nicotinamide: Reaction: Nicotinamide + SAM 1-methylnicotinamide (1-MNA) + S-adenosylhomocysteine (SAH) Expression: Liver, adipose tissue (particularly visceral), smooth muscle, some neurons Regulation: Increased expression in obesity, diabetes, aging, certain cancers Substrates consumed: Nicotinamide (NAD+ precursor) and SAM (methyl donor) 5-Amino-1MQ Inhibition Mechanism: Competitive inhibitor with respect to nicotinamide substrate IC: Submicromolar range for NNMT enzyme Selectivity: Minimal inhibition of other methyltransferases at relevant concentrations Result: Increased intracellular nicotinamide availability for NAD+ salvage pathway Downstream Effects of NNMT Inhibition: 1

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KEY FEATURES High-purity BPC-157 research peptide 5mg lyophilised powder per vial HPLC-MS verified purity (99.67%) Manufactured in accredited laboratories Sterile, tamper-evident vial suitable for laboratory handling Fast, discreet Australia-wide shipping SPECIFICATIONS Product Name BPC-157 Peptide Grade Research Grade Quantity 5mg per vial Form Lyophilised powder Purity 99.67% (HPLC-MS tested) Appearance White/off-white lyophilised powder Storage Conditions Cool, dry environment