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For this group, moving to a compound with a different and more complex mechanism makes logical sense

The 100 mcg per injection dose is considered near the saturation dose higher amounts don't meaningfully increase per-bolus GH output

Your clinician should review your diabetes medications when starting retatrutide, and you should monitor your blood glucose as advised

The mechanism that lowers postprandial glucose also means the stomach retains contents longer, which is relevant to anyone with pre-existing gastroparesis or significant GI motility disorders, and is a theoretical consideration around procedures requiring an empty stomach