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In 2015, Lantos and colleagues reviewed the geographic expansion of Lyme disease in the Southeast and found a marked increase in Lyme disease cases in Virginia, particularly from 2007 onwards with development of a new disease cluster in the southern Virginia mountain region. Since 2009, five counties in North Carolina have been considered endemic for Lyme disease

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Additionally, its role in angiogenesis, the formation of new blood vessels, ensures an adequate blood supply to the damaged areas, expediting the healing process

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