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In addition, second-line treatments such as GnRH agonists effectively reduce pain but are compromised by significant menopausal side effects and challenges with long-term tolerability, which has prompted the development of novel oral GnRH antagonists like elagolix, linzagolix, and relugolix that offer dose-dependent estrogen suppression and rapid reversibility

The distribution of pigments is also partially under genetic control and some genes involved have been identified

ASOs are designed to skip the exon where mutations occur, in the hopes of restoring the proteins function albeit partially

Thanks to their potent antibacterial action, these NPs can reduce microbial adhesion, proliferation, and biofilm growth (Campoccia et al., 2013)