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Finally, brain trauma clinically is often severe enough to generate blood-clots, cellular debris and exudates, each exacerbating local pathophysiology and preventing local drug access

USF1 and USF2, but not c-Myc, can bind to this E-box and overexpression of either one can inhibit the promoter activity (Cheng et al., 2005)

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Change is difficult, disruptive, and full of uncertainty, but the faster and smarter we act individually and collectively, the more we can prevent and lessen the suffering